Forensic Science International: Genetics
Volume 6, Issue 1 , Pages 17-25 , January 2012

A stochastic model of the processes in PCR based amplification of STR DNA in forensic applications

  • Jos Weusten

      Affiliations

    • DSM Resolve, The Maastricht Forensic Institute, P.O. Box 18, 6160 MD Geleen, Urmonderbaan 22, 6167 RD Geleen, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 4647 63819; fax: +31 1026 44780.
    • ,
  • Jos Herbergs

      Affiliations

    • DNalysis Maastricht, The Maastricht Forensic Institute, P.O. Box 1036, 6201 BA Maastricht, Oxfordlaan 70, 6229 EV Maastricht, The Netherlands
    • Tel.: +31 4338 85810; fax: +31 4338 85889.

Received 21 July 2010 ,Revised 3 January 2011 ,Accepted 7 January 2011.

References 

  1. Whitaker JP, Cotton EA, Gill P. A comparison of the characteristics of profiles produced with AmpFlSTR® SGM Plus™ multiplex system for both standard and low copy number (LCN) STR DNA analysis. Forensic Sci. Int. 2001;123:215–223
  2. Gill P, Curran J, Elliot K. A graphical simulation model of the entire DNA process associated with the analysis of short tandem repeat loci. Nucleic Acids Res. 2005;33:632–643
  3. Gill P, Brenner CH, Buckleton JS, Carracedo A, Krawczak M, Mayr WR, et al. DNA commission of the international society of forensic genetics: recommendations on the interpretation of mixtures. Forensic Sci. Int. 2006;160:90–101
  4. Michel S, de Bast A, Vandenbroere I, Froment O. Interpretation of low-copy-number DNA profile after post-PCR purification. Forensic Sci. Int. Genet. 2009;(Suppl. 2):542–543
  5. Cowell RG. Validation of an STR peak area model. Forensic Sci. Int. Genet. 2009;3:193–199
  6. R.G. Cowell, S.L. Lauritzen, J. Mortera, Probabilistic expert systems for handling artifacts in complex DNA mixtures. Forensic Sci. Int. Genet. (2010), doi:10.1016/j.fsigen.2010.03.008.
  7. Petricevic S, Whitaker J, Buckleton J, Vintiner S, Patel J, Simon P, et al. Validation and development of interpretation guidelines for low copy number (LCN) DNA profiling in New Zealand using the AmpFlSTR® SGM Plus™ multiplex. Forensic Sci. Int. Genet. 2010;4:305–310
  8. Gibb AJ, Huell AL, Simmons MC, Brown RM. Characterisation of forward stutter in the AmpFlSTR® SGM Plus® PCR. Sci. Just. 2009;49:24–31
  9. Walsh PS, Fildes NJ, Reynolds R. Sequence analysis and characterization of stutter products at the tetranucleotide repeat locus vWA. Nucleic Acids Res. 1996;24:2807–2812
  10. Leclair B, Frégeau CJ, Bowen KL, Fourney RM. Systematic analysis of stutter percentages and allele peak height and peak area ratios at heterozygous STR loci for forensic casework and database samples. J. Forensic Sci. 2004;49:1–13
  11. Mulero JJ, Chang CW, Lagacé RE, Wang DY, Bas JL, McMahon TP, et al. Development and validation of the AmpFlSTR® MiniFiler™ PCR amplification kit: a miniSTR multiplex for the analysis of degraded and/or PCR inhibited DNA. J. Forensic Sci. 2008;53:838–852
  12. Gill P, Sparkes R, Fereday L, Werrett DJ. Report of the European network of forensic science institutes (ENFSI): formulation and testing of principles to evaluate STR multiplexes. Forensic Sci. Int. 2000;108:1–29
  13. Shinde D, Lai Y, Sun F, Arnheim N. Taq DNA polymerase slippage mutation rates measured by PCR and quasi-likelihood analysis: (CA/GT)n and (A/T)n microsatellites. Nucleic Acids Res. 2003;31:974–980
  14. Weusten JJAM, Wouters PAWM, van Zuijlen MCA, van de Wiel PA. Stochastic processes defining sensitivity and variability of internally calibrated quantitative NASBA-based viral load assays. Nucleic Acids Res. 2002;30:e137
  15. Roeder AD, Elsmore P, Greenhalgh M, McDonald A. Maximizing DNA profiling success from sub-optimal quantities of DNA: a staged approach. Forensic Sci. Int. Genet. 2009;3:128–137
  16. E.A.M. Graham, An Evaluation of Forensic DNA Profiling Techniques Currently Used in the United Kingdom. PhD Thesis October 2007 (date file retrieved from internet: May 31, 2010) (https://lra.le.ac.uk/bitstream/2381/4529/1/PhD%20Thesis%20EAMG%20FINAL%20VERSION.pdf).
  17. Gill P, Whitaker J, Flaxman C, Brown N, Buckleton J. An investigation of the rigor of interpretation rules for STRs derived from less than 100pg of DNA. Forensic Sci. Int. 2000;112:17–40

PII: S1872-4973(11)00016-0

doi: 10.1016/j.fsigen.2011.01.003

Forensic Science International: Genetics
Volume 6, Issue 1 , Pages 17-25 , January 2012

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