Forensic Science International: Genetics
Volume 1, Issue 2 , Pages 148-153 , June 2007

Resolving mtDNA mixtures by denaturing high-performance liquid chromatography and linkage phase determination

  • Phillip B. Danielson

      Affiliations

    • University of Denver, Department of Biological Sciences, 2190 E. Iliff Avenue Rm 102, Denver, CO 80208, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 303 871 2899; fax: +1 303 871 3471.
    • ,
  • Hong-Yu Sun

      Affiliations

    • University of Denver, Department of Biological Sciences, 2190 E. Iliff Avenue Rm 102, Denver, CO 80208, USA
    • Sun Yat-sen University, Department of Forensic Medicine, 74 Zhongshan Rd., Guangzhou, Guangdong 510089, PR China
    • ,
  • Terry Melton

      Affiliations

    • Mitotyping Technologies, LLC, 2565 Park Center Blvd. Suite 200, State College, PA 16801, USA
    • ,
  • Richard Kristinsson

      Affiliations

    • University of Denver, Department of Biological Sciences, 2190 E. Iliff Avenue Rm 102, Denver, CO 80208, USA

Received 25 January 2007 ,Accepted 5 February 2007.

References 

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  3. Wilson MR, et al. Validation of mitochondrial DNA sequencing for forensic casework analysis. Int. J. Legal. Med. 1995;108(2):68–74
  4. Lightowlers RN, et al. Mammalian mitochondrial genetics: heredity, heteroplasmy and disease. Trends Genet. 1997;13(11):450–455
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  8. Emmerson P, et al. Characterizing mutations in samples with low-level mosaicism by collection and analysis of DHPLC fractionated heteroduplexes. Hum. Mutat. 2003;21(2):112–115
  9. Etokebe GE, et al. Physical separation of HLA-A alleles by denaturing high-performance liquid chromatography. Tissue Antigens. 2003;61(6):443–450
  10. Danielson PB, et al. Separating human DNA mixtures using denaturing high-performance liquid chromatography. Expert Rev. Mol. Diagn. 2005;5(1):53–63
  11. Xiao W, Oefner PJ. Denaturing high-performance liquid chromatography: a review. Hum. Mutat. 2001;17(6):439–474
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  13. Huber CG, Oefner PJ, Bonn GK. High-resolution liquid chromatography of oligonucleotides on nonporous alkylated styrene-divinylbenzene copolymers. Anal. Biochem. 1993;212(2):351–358
  14. Huber CG, Oefner PJ, Bonn GK. Rapid and accurate sizing of DNA fragments by ion-pair chromatography on alkylated nonporus poly(styrene-divinylbenzene). Anal. Chem. 1995;67:578–585
  15. O’Donovan MC, et al. Blind analysis of denaturing high-performance liquid chromatography as a tool for mutation detection. Genomics. 1998;52(1):44–49
  16. Kuklin A, et al. Detection of single-nucleotide polymorphisms with the WAVE™ DNA fragment analysis system. Genet. Test. 1997;1:201–206
  17. Underhill PA, et al. Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography. Genome Res. 1997;7(10):996–1005
  18. LaBerge GS, Shelton RJ, Danielson PB. Forensic utility of mitochondrial DNA analysis based on denaturing high-performance liquid chromatography. Croat. Med. J. 2003;44(3):281–288
  19. Huber CG, Oefner PJ, Bonn GK. Rapid analysis of biopolymers on modified non-porous polystyrene-divenylbenzene particles. Chromatographia. 1993;37:653–658

PII: S1872-4973(07)00064-6

doi: 10.1016/j.fsigen.2007.02.008

Forensic Science International: Genetics
Volume 1, Issue 2 , Pages 148-153 , June 2007

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