Forensic Science International: Genetics
Volume 2, Issue 3 , Pages e31-e35, June 2008

Analysis of mutations in father–son pairs with 17 Y-STR loci

  • Amy E. Decker

      Affiliations

    • Biochemical Science Division, National Institute of Sciences and Technology, Gaithersburg, MD 20899-8311, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 301 975 5205; fax: +1 301 975 8505.
    • ,
  • Margaret C. Kline

      Affiliations

    • Biochemical Science Division, National Institute of Sciences and Technology, Gaithersburg, MD 20899-8311, United States
    • ,
  • Janette W. Redman

      Affiliations

    • Biochemical Science Division, National Institute of Sciences and Technology, Gaithersburg, MD 20899-8311, United States
    • ,
  • Thomas M. Reid

      Affiliations

    • DNA Diagnostics Center, Fairfield, OH 45014, United States
    • ,
  • John M. Butler

      Affiliations

    • Biochemical Science Division, National Institute of Sciences and Technology, Gaithersburg, MD 20899-8311, United States

Received 8 May 2007; received in revised form 22 August 2007; accepted 30 August 2007. published online 16 October 2007.

Abstract 

We have examined 389 father/son sample pairs from U.S. Caucasians, African Americans, Hispanics and Asians using the 17 Y-STR loci in the Yfiler™ kit and observed a total of 24 differences between father and son. Thirteen mutations resulted in the gain of a repeat in the son and 11 resulted in a loss of a repeat. All samples resulted in single repeat mutations except one sample which contained a two repeat loss at Y-GATA-H4. Furthermore, two different sample pairs were found to have two mutations. An African American sample pair had a mutation at DYS458 and a second at DYS635 and an Asian sample pair had mutations at DYS439 and Y-GATA-H4.

Keywords: Short tandem repeat, DNA, Y-STR, Mutation rate, DYS19, DYS385a/b, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458

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PII: S1872-4973(07)00144-5

doi:10.1016/j.fsigen.2007.08.016

Forensic Science International: Genetics
Volume 2, Issue 3 , Pages e31-e35, June 2008

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