Genetic admixture and diversity estimations in the Mexican Mestizo population from Mexico City using 15 STR polymorphic markers
Received 20 February 2007; received in revised form 27 August 2007; accepted 30 August 2007. published online 08 October 2007.
Abstract
The 15 AmpFlSTR Identifiler loci D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA were analyzed in a sample of 378 unrelated individuals from Mexico City, Mexico. Significant deviations from HW equilibrium in 14/15 STR loci alleles were not detected. The D18S51 locus had the highest power of discrimination (0.970). Genetic admixture estimations revealed a 69% of Amerindian, 26% of European and 5% of African contribution. Comparative analyses between Mexicans and other neighboring populations reveal significant differences in genetic diversity. Our results are important for future comparative genetic studies in different Latin American ethnic groups, particularly Mexican Mestizos and Amerindians. They should also be helpful in genetics, population evolution, forensic and paternity testing.
aEpidemiological Research and Health Services Unit, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
bImmunobiology and Genetics Laboratory, Instituto Nacional de Enfermedades Respiratorias and Departments of Cancer Immunology and AIDS, DFCI and Pathology Harvard Medical School, Boston, MA, USA
cEscuela Nacional de Antropología e Historia, Instituto Nacional de Antropología e Historia, Mexico City, Mexico
dDepartment of Physiology and Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
eDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Corresponding author at: Department of Physiology and Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano #1, Col. Sección XVI, Tlalpan 14050, Mexico City, Mexico. Tel.: +52 55 5573 29 11x1268.
ABSTRACT