Forensic Science International: Genetics
Volume 2, Issue 3 , Pages e37-e39, June 2008

Genetic admixture and diversity estimations in the Mexican Mestizo population from Mexico City using 15 STR polymorphic markers

  • Teresa Juárez-Cedillo

      Affiliations

    • Epidemiological Research and Health Services Unit, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    • ,
  • Joaquín Zuñiga

      Affiliations

    • Immunobiology and Genetics Laboratory, Instituto Nacional de Enfermedades Respiratorias and Departments of Cancer Immunology and AIDS, DFCI and Pathology Harvard Medical School, Boston, MA, USA
    • ,
  • Victor Acuña-Alonzo

      Affiliations

    • Escuela Nacional de Antropología e Historia, Instituto Nacional de Antropología e Historia, Mexico City, Mexico
    • ,
  • Nonanzit Pérez-Hernández

      Affiliations

    • Department of Physiology and Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
    • ,
  • José Manuel Rodríguez-Pérez

      Affiliations

    • Department of Physiology and Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
    • ,
  • Rodrigo Barquera

      Affiliations

    • Escuela Nacional de Antropología e Historia, Instituto Nacional de Antropología e Historia, Mexico City, Mexico
    • ,
  • Guillermo J. Gallardo

      Affiliations

    • Department of Physiology and Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
    • ,
  • Rosalinda Sánchez-Arenas

      Affiliations

    • Epidemiological Research and Health Services Unit, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    • ,
  • Maria del Carmen García-Peña

      Affiliations

    • Epidemiological Research and Health Services Unit, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    • ,
  • Julio Granados

      Affiliations

    • Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City, Mexico
    • ,
  • Gilberto Vargas-Alarcón

      Affiliations

    • Department of Physiology and Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
    • Corresponding Author InformationCorresponding author at: Department of Physiology and Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano #1, Col. Sección XVI, Tlalpan 14050, Mexico City, Mexico. Tel.: +52 55 5573 29 11x1268.

Received 20 February 2007; received in revised form 27 August 2007; accepted 30 August 2007. published online 08 October 2007.

Abstract 

The 15 AmpFlSTR Identifiler loci D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA were analyzed in a sample of 378 unrelated individuals from Mexico City, Mexico. Significant deviations from HW equilibrium in 14/15 STR loci alleles were not detected. The D18S51 locus had the highest power of discrimination (0.970). Genetic admixture estimations revealed a 69% of Amerindian, 26% of European and 5% of African contribution. Comparative analyses between Mexicans and other neighboring populations reveal significant differences in genetic diversity. Our results are important for future comparative genetic studies in different Latin American ethnic groups, particularly Mexican Mestizos and Amerindians. They should also be helpful in genetics, population evolution, forensic and paternity testing.

Keywords: STR, Frequency, Mexicans, Admixture estimation, Population genetics

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S1872-4973(07)00145-7

doi:10.1016/j.fsigen.2007.08.017

Forensic Science International: Genetics
Volume 2, Issue 3 , Pages e37-e39, June 2008

Article Tools