A case of tri-allelic pattern at locus D3S1358 on chromosome 3p21 inherited from paternal grandmother

Received 19 March 2008; received in revised form 13 May 2008; accepted 6 June 2008. published online 22 July 2008.

Abstract

We are reporting a case of tri-allelic inheritance at locus D3S1358 commonly used for genetic identification in forensic DNA testing. This case was encountered during routine paternity testing using commercial DNA profiling kits. The tri-allelic inheritance identified was probably a result of duplication at this locus, supported by the equal peak intensities and inheritance pattern from grandparent to child.

Keywords: STRs, Tri-allelic inheritance, DNA profiling, Forensics, D3S1358

MLS BioDNA Ltd, KBIC 2150–2160, Industrial Estate, Kordin PLA08, Malta

Corresponding author. Tel.: +356 23980148; fax: +356 23980161.

PII: S1872-4973(08)00090-2

doi:10.1016/j.fsigen.2008.06.002

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