Analysis of 10 X-linked tetranucleotide markers in mixed and isolated populations

Zarrabeitia, María T.; Pinheiro, Fátima; de Pancorbo, Marian M.; Cainé, Laura; Cardoso, Sergio; Gusmão, Leonor; Riancho, José A.

doi:10.1016/j.fsigen.2008.10.001

« Previous Next »Forensic Science International: Genetics
Volume 3, Issue 2 , Pages 63-66, March 2009

Analysis of 10 X-linked tetranucleotide markers in mixed and isolated populations

María T. Zarrabeitia
- Unit of Legal Medicine, University of Cantabria, Av Herrera Oria s/n, 39011 Santander, Spain
- Corresponding author. Tel.: +34 942201984; fax: +34 942201903.
Fátima Pinheiro
- National Institute of Legal Medicine, I.P. - North Delegation and Health Sciences Faculty, Fernando Pessoa University, Porto, Portugal
Marian M. de Pancorbo
- ADN Bank, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain
Laura Cainé
- National Institute of Legal Medicine, I.P. - North Delegation and Health Sciences Faculty, Fernando Pessoa University, Porto, Portugal
Sergio Cardoso
- ADN Bank, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain
Leonor Gusmão
- IPATIMUP Institute of Pathology and Molecular Immunology, University of Porto, Porto, Portugal
José A. Riancho
- Department of Medicine, Hospital U.M. Valdecilla, University of Cantabria, Santander, Spain

Received 3 August 2008; received in revised form 21 September 2008; accepted 2 October 2008. published online 19 November 2008.

Abstract

We have applied a recently described X-STRs decaplex to characterize four population groups of the Iberian Peninsula, including two well mixed populations and two relatively isolated ones from Northern Spain, in order to get a better insight about the characteristics of X-STRs in those population types between-population differences in allelic frequencies were relatively small. Nevertheless, Fst values were between 0.2 and 2.7%, figures higher than usually reported for autosomic STRs. This result suggests that when forensic cases originate from relatively isolated groups in western Europe, and a specific reference database is not available, it is probably safe to include a Fst-based correction in the calculations of matching or kinship probabilities.

Keywords: STRs, X chromosome, Population genetics