Forensic Science International: Genetics
Volume 4, Issue 3 , Pages e75-e78, April 2010

Assembly of a large Y-STR haplotype database for the Czech population and investigation of its substructure

  • Jan Zastera

      Affiliations

    • Laboratory for Molecular Genetics and Oncology, Genomac International, Ltd., Bavorska 856, CZ15541 Prague 5, Czech Republic
    • ,
  • Lutz Roewer

      Affiliations

    • Department of Forensic Genetics, Institute for Legal Medicine and Forensic Sciences, Charite–Universitätsmedizin Berlin, Germany
    • ,
  • Sascha Willuweit

      Affiliations

    • Department of Forensic Genetics, Institute for Legal Medicine and Forensic Sciences, Charite–Universitätsmedizin Berlin, Germany
    • ,
  • Patrik Sekerka

      Affiliations

    • Laboratory for Molecular Genetics and Oncology, Genomac International, Ltd., Bavorska 856, CZ15541 Prague 5, Czech Republic
    • ,
  • Lucie Benesova

      Affiliations

    • Laboratory for Molecular Genetics and Oncology, Genomac International, Ltd., Bavorska 856, CZ15541 Prague 5, Czech Republic
    • ,
  • Marek Minarik

      Affiliations

    • Laboratory for Molecular Genetics and Oncology, Genomac International, Ltd., Bavorska 856, CZ15541 Prague 5, Czech Republic
    • Corresponding Author InformationCorresponding author. Tel.: +420 224 458 048; fax: +420 224 458 021.

Received 2 June 2009; accepted 8 June 2009. published online 13 July 2009.

Abstract 

Twelve Y-chromosomal short tandem repeats (Y-STR) (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a, DYS385b, DYS437, DYS438, and DYS439) included in the PowerPlex Y™ Kit (Promega Corporation, Madison, USA) were studied for 1750 unrelated males living in 14 regions of the Czech Republic. A total of 1148 different haplotypes were found. The overall haplotype diversity (HD) was determined as 0.998. Analysis of Molecular Variance (AMOVA) reveals non-significant distances between regions concerning their haplotype distribution, thus allowing to use the whole sample as a representative reference database of the Czech Republic. Median network analysis shows a remarkable bipartite composition of the Czech haplotypes, falling in distinct clusters with Eastern and Western European roots.

Keywords: Y-STR, Population, Czech, Haplotype, Haplogroup, Genograf

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PII: S1872-4973(09)00096-9

doi:10.1016/j.fsigen.2009.06.005

Forensic Science International: Genetics
Volume 4, Issue 3 , Pages e75-e78, April 2010

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