Genetic polymorphisms of eight X-chromosomal STR loci in the population of Japanese

Abstract 

The genetic polymorphisms of eight X-chromosomal short tandem repeats (STR) DXS10135, DXS8378, DXS7132, DXS10074, HPRTB, DXS10101, DXS10134 and DXS7423 were analyzed in a sample of 492 unrelated males (283) and females (209) from the Japanese population. Multiplex PCR amplification was performed using the Mentype^® Argus X-8 PCR amplification kit. The haplotype frequencies within the four linkage groups were studied for the 283 examined Japanese males. Allele frequencies of eight X-STR loci were calculated separately for males and females, and exact tests demonstrated no significant deviations from Hardy–Weinberg equilibrium. Several microvariant and rare alleles were observed, and forensic efficiency parameters were calculated. The combined powers of discrimination of the loci in men and women were 0.999995 and 0.9999999999988, respectively.

Keywords: STR, X-chromosome, Allele frequencies, Haplotype, Genetic polymorphism