Forensic Science International: Genetics
Volume 5, Issue 3 , Pages e49-e52, June 2011

Strong intra- and inter-continental differentiation revealed by Y chromosome SNPs M269, U106 and U152

  • Fulvio Cruciani

      Affiliations

    • Dipartimento di Genetica e Biologia Molecolare, Sapienza Università di Roma, Rome, Italy
    • ,
  • Beniamino Trombetta

      Affiliations

    • Dipartimento di Genetica e Biologia Molecolare, Sapienza Università di Roma, Rome, Italy
    • ,
  • Cheyenne Antonelli

      Affiliations

    • Dipartimento di Genetica e Biologia Molecolare, Sapienza Università di Roma, Rome, Italy
    • ,
  • Roberto Pascone

      Affiliations

    • Dipartimento di Pediatria, Sapienza Università di Roma, Rome, Italy
    • ,
  • Guido Valesini

      Affiliations

    • Dipartimento di Clinica e Terapia Medica, Sapienza Università di Roma, Rome, Italy
    • ,
  • Valentina Scalzi

      Affiliations

    • Dipartimento di Clinica e Terapia Medica, Sapienza Università di Roma, Rome, Italy
    • ,
  • Giuseppe Vona

      Affiliations

    • Dipartimento di Biologia Sperimentale, Università di Cagliari, Cagliari, Italy
    • ,
  • Bela Melegh

      Affiliations

    • Department of Medical Genetics, University of Pécs, Pécs, Hungary
    • ,
  • Boris Zagradisnik

      Affiliations

    • Laboratory of Medical Genetics, University Medical Centre Maribor, Maribor, Slovenia
    • ,
  • Guenter Assum

      Affiliations

    • Institut für Humangenetik, Universität Ulm, Ulm, Germany
    • ,
  • Georgi D. Efremov

      Affiliations

    • Research Center for Genetic Engineering and Biotechnology, Macedonian Academy of Sciences and Arts, Skopje, The Former Yugoslav Republic of Macedonia
    • ,
  • Daniele Sellitto

      Affiliations

    • Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy
    • ,
  • Rosaria Scozzari

      Affiliations

    • Dipartimento di Genetica e Biologia Molecolare, Sapienza Università di Roma, Rome, Italy
    • Corresponding Author InformationCorresponding author at: Dipartimento di Genetica e Biologia Molecolare, Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy. Tel.: +39 06 49912826/49912924; fax: +39 06 4456866.

Received 3 May 2010; received in revised form 23 July 2010; accepted 28 July 2010. published online 26 August 2010.

Abstract 

More than 2700 unrelated individuals from Europe, northern Africa and western Asia were analyzed for the marker M269, which defines the Y chromosome haplogroup R1b1b2. A total of 593 subjects belonging to this haplogroup were identified and further analyzed for two SNPs, U106 and U152, which define haplogroups R1b1b2g and R1b1b2h, respectively. These haplogroups showed quite different frequency distribution patterns within Europe, with frequency peaks in northern Europe (R1b1b2g) and northern Italy/France (R1b1b2h).

Keywords: Y chromosome SNPs, R1b haplogroup, Phylogeography, European populations

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PII: S1872-4973(10)00117-1

doi:10.1016/j.fsigen.2010.07.006

Forensic Science International: Genetics
Volume 5, Issue 3 , Pages e49-e52, June 2011

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