Abstract
A parentage case is described that revealed a potentially erroneous exclusion from
paternity in three systems, two on chromosome 21 and one on chromosome Y. Follow-up
tests, especially of chromosome 21, were subsequently performed. Actually, the child's
chromosome 21 showed alleles of maternal but not of paternal origin being consistent
with a maternal uniparental disomy of chromosome 21. The third genetic incompatibility
was observed at the Y chromosome and attributed to a usual one-step de novo mutation. This case is emphasizing the (generally adopted) requirement that an exclusion
from paternity must not be based on the absence of paternal alleles at genetic systems
all located on the same chromosome. In fact, the need for extended typing programmes
is demonstrated.
Keywords
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Article info
Publication history
Published online: November 14, 2008
Accepted:
September 24,
2008
Received in revised form:
September 22,
2008
Received:
August 27,
2008
Identification
Copyright
© 2008 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
