Advertisement
Announcement of population data| Volume 3, ISSUE 4, e119-e125, September 2009

Mitochondrial DNA control region variation in a population sample from Hong Kong, China

  • Jodi A. Irwin
    Correspondence
    Corresponding author. Tel.: +1 301 319 0244; fax: +1 301 295 5932.
    Affiliations
    Armed Forces DNA Identification Laboratory, 1413 Research Boulevard, Building 101, Rockville, MD 20850, United States
    Search for articles by this author
  • Jessica L. Saunier
    Affiliations
    Armed Forces DNA Identification Laboratory, 1413 Research Boulevard, Building 101, Rockville, MD 20850, United States
    Search for articles by this author
  • Philip Beh
    Affiliations
    Department of Pathology, The University of Hong Kong, 3/F, University Pathology Building, Queen Mary Hospital, Hong Kong
    Search for articles by this author
  • Katharine M. Strouss
    Affiliations
    Armed Forces DNA Identification Laboratory, 1413 Research Boulevard, Building 101, Rockville, MD 20850, United States
    Search for articles by this author
  • Carla D. Paintner
    Affiliations
    Armed Forces DNA Identification Laboratory, 1413 Research Boulevard, Building 101, Rockville, MD 20850, United States
    Search for articles by this author
  • Author Footnotes
    1 Present address: International Commission on Missing Persons, Alipašina 45A, 71000 Sarajevo, Bosnia and Herzegovina.
    Thomas J. Parsons
    Footnotes
    1 Present address: International Commission on Missing Persons, Alipašina 45A, 71000 Sarajevo, Bosnia and Herzegovina.
    Affiliations
    Armed Forces DNA Identification Laboratory, 1413 Research Boulevard, Building 101, Rockville, MD 20850, United States
    Search for articles by this author
  • Author Footnotes
    1 Present address: International Commission on Missing Persons, Alipašina 45A, 71000 Sarajevo, Bosnia and Herzegovina.
Published:December 12, 2008DOI:https://doi.org/10.1016/j.fsigen.2008.10.008

      Abstract

      Entire mitochondrial control region sequences were generated from 377 unrelated individuals from urban Hong Kong. In line with other control region datasets from China, the sample from Hong Kong exhibited significant genetic diversity that was reflected in a random match probability of 0.19% and a mean pairwise difference of 13.14. A total of 305 haplotypes were identified, of which 262 were unique. These sequences will be made publicly available to serve as forensic mtDNA reference data for China.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Forensic Science International: Genetics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Brandstätter A.
        • Peterson C.T.
        • Irwin J.A.
        • Mpoke S.
        • Koech D.K.
        • Parson W.
        • Parsons T.J.
        Mitochondrial DNA control region sequences from Nairobi (Kenya): inferring phylogenetic parameters for the establishment of a forensic database.
        Int. J. Legal Med. 2004; 118: 294-306
        • Irwin J.
        • Saunier J.
        • Strouss K.
        • Sturk K.
        • Diegoli T.
        • Just R.
        • Coble M.
        • Parson W.
        • Parsons T.
        Development and expansion of high quality control region databases to improve forensic mtDNA evidence interpretation.
        For. Sci. Int. Genet. 2007; 1: 154-157
        • Anderson S.
        • Bankier A.T.
        • Barrell B.G.
        • de Bruijn M.H.
        • Coulson A.R.
        • Drouin J.
        • Eperon I.C.
        • Nierlich D.P.
        • Roe B.A.
        • Sanger F.
        • Schreier P.H.
        • Smith A.J.
        • Staden R.
        • Young I.G.
        Sequence and organization of the human mitochondrial genome.
        Nature. 1981; 290: 457-465
        • Andrews R.M.
        • Kubacka I.
        • Chinnery P.F.
        • Lightowlers R.N.
        • Turnbull D.M.
        • Howell N.
        Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA.
        Nat. Genet. 1999; 23: 147
        • Brandstätter A.
        • Sänger T.
        • Lutz-Benengel S.
        • Parson W.
        • Beraud-Colomb E.
        • Wen B.
        • Kong Q.-P.
        • Bravi C.
        • Bandelt H.-J.
        Phantom mutation hotspots in human mitochondrial DNA.
        Electrophoresis. 2005; 26: 3414-3429
        • Bandelt H.-J.
        • Forster P.
        • Röhl A.
        Median-joining networks for inferring intraspecific phylogenies.
        Mol. Biol. Evol. 1999; 16: 37-48
        • Forster P.
        • Torroni A.
        • Renfrew C.
        • Röhl A.
        Phylogenetic star contraction applied to Asian and Papuan mtDNA evolution.
        Mol. Biol. Evol. 2001; 18: 1864-1881
        • Polzin T.
        • Daneschmand S.V.
        On Steiner trees and minimum spanning trees in hypergraphs.
        Oper. Res. Lett. 2003; 31: 12-20
        • Lee H.Y.
        • Yoo J.
        • Park M.J.
        • Chung U.
        • Shin K.J.
        Mitochondrial DNA control region sequences in Koreans: identification of useful variable sites and phylogenetic analysis for mtDNA data quality control.
        Int. J. Legal Med. 2006; 120: 5-14
        • Kong Q.P.
        • Bandelt H.J.
        • Sun C.
        • Yao Y.G.
        • Salas A.
        • Achilli A.
        • Wang C.Y.
        • Zhong L.
        • Zhu C.L.
        • Wu S.F.
        • Torroni A.
        • Zhang Y.P.
        Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations.
        Hum. Mol. Genet. 2006; 15: 2076-2086
        • Palanichamy M.G.
        • Sun C.
        • Agrawal S.
        • Bandelt H.J.
        • Kong Q.P.
        • Khan F.
        • Wang C.Y.
        • Chaudhuri T.K.
        • Palla V.
        • Zhang Y.P.
        Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on complete sequencing: implications for the peopling of South Asia.
        Am. J. Hum. Genet. 2004; 75: 966-978
        • Hill C.
        • Soares P.
        • Mormina M.
        • Macaulay V.
        • Meehan W.
        • Blackburn J.
        • Clarke D.
        • Maripa Raha J.
        • Ismail P.
        • Bulbeck D.
        • Oppenheimer S.
        • Richards M.
        Phylogeography and ethnogenesis of Aboriginal Southeast Asians.
        Mol. Biol. Evol. 2006; 23: 2480-2491
        • Kivisild T.
        • Tolk H.
        • Parik J.
        • Wang Y.
        • Papiha S.
        • Bandelt H.J.
        • Villems R.
        The emerging limbs and twigs of the East Asian mtDNA tree.
        Mol. Biol. Evol. 2002; 19: 1737-1751
        • Tanaka M.
        • Cabrera V.
        • Gonzalez A.
        • Larruga J.
        • Takeyasu T.
        • Fuku N.
        • Guo L.-J.
        • et al.
        Mitochondrial genome variation in eastern Asia and the peopling of Japan.
        Genome Res. 2004; 14: 1832-1850
        • Metspalu M.
        • Kivisild T.
        • Metspalu E.
        • Parik J.
        • Hudjashov G.
        • Kaldma K.
        • Serk P.
        • Karmin M.
        • Behar D.
        • Gilbert T.
        • Endicott P.
        • Mastana S.
        • Papiha S.
        • Skorecki K.
        • Torroni A.
        • Villems R.
        Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans.
        BMC Genet. 2004; 5: 26
        • Yao Y.G.
        • Kong Q.P.
        • Bandelt H.J.
        • Kivisild T.
        • Zhang Y.P.
        Phylogeographic differentiation of mitochondrial DNA in Han Chinese.
        Am. J. Hum. Genet. 2002; 70: 635-651
        • Derenko M.
        • Malyarchuk B.
        • Grzybowski T.
        • Denisova G.
        • Dambueva I.
        • Perkova M.
        • Dorzhu C.
        • Luzina F.
        • Lee H.-K.
        • Vanecek T.
        • Villems R.
        • Zakharov I.
        Phylogeographic analysis of mitochondrial DNA in northern Asian populations.
        Am. J. Hum. Genet. 2007; 81: 1025-1041
        • Sun C.
        • Kong Q.P.
        • Palanichamy M.
        • Agrawal S.
        • Bandelt H.J.
        • Yao Y.G.
        • Khan F.
        • Zhu C.L.
        • Chaudhuri T.K.
        • Zhang Y.P.
        The dazzling array of basal branches in the mtDNA macrohaplogroup M from India as inferred from complete genomes.
        Mol. Biol. Evol. 2006; 23: 683-690
        • Parson W.
        • Dür A.
        EMPOP—a forensic mtDNA database.
        FSI: Genet. 2007; 1: 88-92
        • Zimmermann B.
        • Brandstätter A.
        • Duftner N.
        • Niederwieser D.
        • Spiroski M.
        • Arsov T.
        • Parson W.
        Mitochondrial DNA control region population data from Macedonia.
        FSI: Genet. 2007; 1: e4-e9
        • Li H.
        • Cai S.
        • Winograd-Cort E.
        • Wen B.
        • Cheng X.
        • Qin Z.
        • Liu W.
        • Liu Y.
        • Pan S.
        • Qian J.
        • Tan C.C.
        • Jin L.
        Mitochondrial DNA diversity and population differentiation in southern East Asia.
        Am. J. Phys. Anthropol. 2007; 134: 481-488
        • Allard M.W.
        • Wilson M.R.
        • Monson K.L.
        • Budowle B.
        Control region sequences for East Asian individuals in the Scientific Working Group on DNA analysis methods forensic mtDNA data set.
        Legal Med. 2004; 6: 11-24