Abstract
Autosomal and Y-chromosomal STR markers have been routinely used in kinship analyses
already for over a decade, augmented by mitochondrial DNA in more complex cases questioning
the maternal relationships of the samples. Recently, a commercial X-chromosome typing
kit Mentype Argus X-8 was introduced to supplement the existing forensic toolkit.
In this study, X-STR allele frequencies and population diversity indices in two ethnic
groups, the Finnish and the Somali, are reported. Several previously unreported alleles
and features in the allelic distribution were observed, some of which were further
investigated with a small set of family data. Most notably, several alleles showed
significant frequency differences between sexes, yet no obvious explanation for this
discrepancy was found. As a demonstration of X-chromosome analysis in practice, we
describe two family reunion cases, where the X-STR data was successfully utilized.
Keywords
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References
- DNA typing and genetic mapping with trimeric and tetrameric tandem repeats.Am. J. Hum. Genet. 1991; 49: 746-756
- Genetic data of 10 X-STRs in a Spanish population sample.Forensic Sci. Int. 2007; 173: 193-196
- 16 X-chromosome STR loci frequency data from a German population.Forensic Sci. Int. 2001; 124: 215-218
- Population genetic evaluation of eight X-chromosomal short tandem repeat loci using Mentype Argus X-8 PCR amplification kit.FSI Genet. 2008; 2: 69-74
- Hungarian population data of eight X-linked markers in four linkage groups.Forensic Sci. Int. 2008; 175: 73-78
- Resolving paternity relationships using X-chromosome STRs and Bayesian networks.J. Forensic Sci. 2007; 52: 895-897
- Use of X-linked markers for forensic purposes.Int. J. Legal Med. 2003; 117: 67-74
- Population data of four X-chromosome markers in Tuscany, and their use in a deficiency paternity case.Forensic Sci. Int. 2003; 137: 215-216
- Arlequin (version 3.0): an integrated software package for population genetics data analysis.Evol. Bioinform. Online. 2005; 1: 47-50
- Performing the exact test of Hardy–Weinberg proportion for multiple alleles.Biometrics. 1992; 48: 361-372
- Construction of a genetic linkage map in man using restriction fragment length polymorphisms.Am. J. Hum. Genet. 1980; 32: 314-331
- Duplex PCR of the Y-27H39 and HPRT loci with reference to Japanese population data on the HPRT locus.Nihon Hoigaku Zasshi. 1997; 51: 67-69
- Zur Verwendung der sauren Erythrocytenphosphatase bei der Vaterschaftsbegutachtung.Dtsch. Z. Gerichtl. Med. 1968; 64: 127-146
- Development of a highly polymorphic STR marker for identity testing purposes at the human androgen receptor gene (HUMARA).J. Forensic Sci. 1998; 43: 1046-1049
- Is the prevalence of Klinefelter syndrome increasing?.Eur. J. Hum. Genet. 2008; 16: 163-170
Article info
Publication history
Published online: March 18, 2009
Identification
Copyright
© 2009 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
