Abstract
A comparative analysis of two Y-STR loci sets was conducted on a population sample
of 224 individuals, 114 Caucasians and 110 African Americans. One set of loci, designated
the OSU 10-locus set, comprises variable, single copy, male-specific loci that are
dispersed across the Y-chromosome. Parallel evaluations were performed using the 10
Y-chromosome loci most frequently used for forensic analysis, the loci chosen as the
SWGDAM Y-STR loci. The OSU 10-locus set had a greater average number of alleles per
locus and higher average gene diversity than the SWGDAM loci. The OSU 10-locus set
found 220 unique haplotypes in 224 individuals. In ∼6000 pairwise haplotype comparisons
for each population with each set of loci, the OSU 10-locus set also yielded a greater
average number of allelic differences per pair than the SWGDAM loci. Finally, the
overall linkage disequilibrium levels were lower for the OSU 10-locus set in the Caucasian
population. In general, the OSU 10-locus set revealed a higher power of discrimination
than the SWGDAM set.
Keywords
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References
Bureau of Justice Statistics, U.S. Department of Justice, Office of Justice Programs. Table 38. Personal crimes of violence, 2006: percent distribution of single-offender victimizations, by type of crime and perceived gender of offender, http://www.ojp.usdoj.gov/bjs.
- European y-chromosomal lineages in polynesians: a contrast to the population structure revealed by mtDNA.Am. J. Hum. Genet. 1998; 63: 1793-1806
- Sex-specific migration patterns in central Asian populations, revealed by analysis of Y-chromosome short tandem repeats and mtDNA.Am. J. Hum. Genet. 1999; 65: 208-219
- Human Y-chromosome derived cloned DNA-sequences.Cytogenet. Cell Genet. 1985; 40: 571
- Homologous loci DXYS156X and DXYS156Y contain a polymorphic pentanucleotide repeat (TAAAA)n and map to human X and Y chromosomes.Hum. Mutat. 1994; 4: 208-211
- Highly informative compound haplotypes for the human Y-chromosome.Hum. Mol. Genet. 1994; 3: 115-123
- Recurrent duplication and deletion polymorphisms on the long arm of the Y chromosome in normal males.Hum. Mol. Genet. 1996; 5: 1767-1775
- Evaluation of Y-chromosomal STRs: a multicenter study.Int. J. Legal Med. 1997; 110 (141–129): 125-133
- New, male-specific microsatellite markers from the human Y chromosome.Genomics. 1999; 57: 433-437
- Identification and characterisation of novel human Y-chromosomal microsatellites from sequence database information.Nucleic Acids Res. 2000; 28: e8
- Identification and characterization of two novel human polymorphic STRs on the Y chromosome.Int. J. Legal Med. 2001; 115: 54-56
- High resolution Y chromosome typing: 19 STRs amplified in three multiplex reactions.Forensic Sci. Int. 2002; 125: 42-51
- Characterization and haplotype analysis of the polymorphic Y-STRs DYS443, DYS444 and DYS445 in a Japanese population.Int. J. Legal Med. 2002; 116: 191-194
- Forensic value of 14 novel STRs on the human Y chromosome.Forensic Sci. Int. 2002; 130: 97-111
- A comprehensive survey of human Y-chromosomal microsatellites.Am. J. Hum. Genet. 2004; 74: 1183-1197
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.Nature. 2003; 423: 825-837
- Duplications of the AZFa region of the human Y chromosome are mediated by homologous recombination between HERVs and are compatible with male fertility.Hum. Mol. Genet. 2003; 12: 341-347
National Center for Forensic Science associated with the University of Central Florida in conjunction with the Y-STR Consortium, US Y-STR Database, http://www.usystrdatabase.org.
L. Roewer, S. Willuweit, Y chromosome haplotype reference database (YHRD), http://YHRD.org.
- Y-chromosomal STR haplotypes in a population sample from Bavaria.Int. J. Legal Med. 2000; 113: 189-192
- DXYS267: DYS393 and its X chromosome counterpart.Forensic Sci. Int. 2000; 112: 111-121
- Molecular characterization and population study of an X chromosome homolog of the Y-linked microsatellite DYS391.Gene. 2000; 247: 233-240
- Haplotype diversity of 16 Y-chromosomal STRs in three main ethnic populations (Malays, Chinese and Indians) in Malaysia.Forensic Sci. Int. 2007; 167: 70-76
- Twelve short tandem repeat loci Y chromosome haplotypes: Genetic analysis on populations residing in North America.Forensic Sci. Int. 2005; 150: 1-15
- High-throughput Y-STR typing of US populations with 27 regions of the Y chromosome using two multiplex PCR assays.Forensic Sci. Int. 2004; 139: 107-121
- Chromosomal duplications along the Y-chromosome and their potential impact on Y-STR interpretation.J. Forensic Sci. 2005; 50: 853-859
- Population data for seven Y-chromosome STR loci from three different population groups residing in Connecticut.J. Forensic Sci. 2003; 48: 435-437
- A case of double alleles at three Y-STR loci: forensic implications.Int. J. Legal Med. 2005; 119: 223-225
- Comprehensive annotated STR physical map of the human Y chromosome: forensic implications.Legal Med. 2006; 8: 110-120
- DNA Commission Of The International Society Of Forensic Genetics: recommendations on forensic analysis using Y-chromosome STRs.Int. J. Legal Med. 2001; 114: 305-309
- Development and validation of the AmpFlSTR (R) Yfiler (TM) PCR amplification kit: a male specific, single amplification 17 Y-STR multiplex system.J. Forensic Sci. 2006; 51: 64-75
SWGDAM, Report on the Current Activities of the Scientific Working Group on DNA Analysis Methods Y-STR Subcomittee, Forensic Sci. Commun. 6 (2004) 1–2.
- Population data for four population groups from the United States for the eleven Y-chromosome STR loci recommended by SWGDAM.J. Forensic Sci. 2006; 51: 700-702
- Utility of the Y-STR typing systems Y-PLEX (TM) 6 and Y-PLEX (TM) 5 in forensic casework and 11 Y-STR haplotype database for three major population groups in the United States.J. Forensic Sci. 2004; 49: 691-700
- SWGDAM developmental validation of a 19-locus Y-STR system for forensic casework.J. Forensic Sci. 2004; 49: 668-683
- Genepop (Version-1.2)-population-genetics software for exact tests and ecumenicism.J. Hered. 1995; 86: 248-249
- Apparent intrachromosomal exchange on the human Y chromosome explained by population history.Eur. J. Hum. Genet. 2003; 11: 304-314
- Separate analysis of DYS385a and b versus conventional DYS385 typing: is there forensic relevance?.Int. J. Legal Med. 2005; 119: 1-9
- DNA Commission of the International Society of Forensic Genetics (ISFG): an update of the recommendations on the use of Y-STRs in forensic analysis.Int. J. Legal Med. 2006; 120: 191-200
- Extending STR markers in Y chromosome haplotypes.Int. J. Legal Med. 2003; 117: 27-33
- Chromosome Y microsatellites: population genetic and evolutionary aspects.Int. J. Legal Med. 1997; 110: 134-149
- Development and validation of the Y-PLEX (TM) 5, a Y-chromosome STR genotyping system, for forensic casework.J. Forensic Sci. 2003; 48: 985-1000
- Development and validation of a multiplexed Y-chromosome STR genotyping system, Y-PLEX (TM) 6, for forensic casework.J. Forensic Sci. 2003; 48: 93-103
B. Budowle, Understanding and Interpreting Y STR Evidence, Paper Presented at Y-STR Analysis on Forensic Casework Workshop American Academy of Forensic Sciences 56th Annual Meeting, Dallas, Texas, 2004.
Article info
Publication history
Published online: May 18, 2009
Accepted:
March 29,
2009
Received in revised form:
March 15,
2009
Received:
June 20,
2008
Identification
Copyright
© 2009 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
