A badly decomposed body required identification by means of DNA analysis. A brother and sister of the deceased were available as reference subjects. Although investigation of Y-chromosomal markers established an exclusion condition, autosomal markers suggested a positive identification. In order to increase the reliability of the tests, X-chromosomal markers were also investigated. This analysis showed the body to have an XXY genotype (Klinefelter's syndrome). A number of hypotheses were assessed using biostatistical methods, ultimately resulting in a definite identification. The special aspect of Klinefelter's syndrome proved highly useful for biostatistical analysis.
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Published online: March 28, 2011
Accepted: February 21, 2011
Received in revised form: February 14, 2011
Received: October 28, 2010
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.