Abstract
A badly decomposed body required identification by means of DNA analysis. A brother
and sister of the deceased were available as reference subjects. Although investigation
of Y-chromosomal markers established an exclusion condition, autosomal markers suggested
a positive identification. In order to increase the reliability of the tests, X-chromosomal
markers were also investigated. This analysis showed the body to have an XXY genotype
(Klinefelter's syndrome). A number of hypotheses were assessed using biostatistical
methods, ultimately resulting in a definite identification. The special aspect of
Klinefelter's syndrome proved highly useful for biostatistical analysis.
Keywords
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References
- Program for the computation of plausibilities of paternity. I. Description of program.Z. Rechtsmed. 1976; 78: 227-242
- ISFG: recommendations on biostatistics in paternity testing.Forensic Sci. Int. Genet. 2007; 1 ([Epub 2007 August 6; Review]): 223-231
- Klinefelter syndrome: clinical and molecular aspects.Expert Rev. Mol. Diagn. 2010; 10: 765-776
- An autopsy case of Klinefelter's syndrome suspected and its DNA analysis.Forensic Sci. Int. Genet. 2000; 113: 119-125
Article info
Publication history
Published online: March 28, 2011
Accepted:
February 21,
2011
Received in revised form:
February 14,
2011
Received:
October 28,
2010
Identification
Copyright
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
