Abstract
Chile is a disproportionately long and narrow country defined by the southern Andes
and Pacific coastline where a level of genetic sub-structure resulting from distances
of several thousand kilometers might be expected across the most distantly separated
regions. Although STR databases created for the Chilean Legal Medical Service indicate
an absence of sub-structure, such a characteristic requires further exploration when
introducing additional forensic markers. Notably, Single Nucleotide Polymorphisms
(SNPs) have a much lower mutation rate than STRs and can show more stable distributions
of genetic variation if population movement is restricted. In this study we evaluated
451 Chilean urban samples from the North, North-Central, Central, South-Central and
South regions of Chile for the 52 SNPs of the SNPforID forensic identification panel to explore the underlying genetic structure of Chilean
populations. Results reveal similar genetic distances between groups suggesting a
single SNP database for the whole of Chile is appropriate. To further understand the
genetic composition of Chilean populations that comprise the bulk of individuals with
both European and Native American ancestries, ancestral membership proportions were
evaluated and pairwise comparisons to other American populations were made.
Keywords
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Article info
Publication history
Published online: January 09, 2014
Accepted:
December 24,
2013
Received in revised form:
December 20,
2013
Received:
November 5,
2013
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
