Highlights
- •Sampled 501 unrelated individuals from the Turkish Cypriot population of Cyprus.
- •Allelic frequencies and statistical parameters of forensic interest were analyzed.
- •No significant deviations from the Hardy-Weinberg equilibrium were observed.
- •Locus-by-locus comparisons revealed significant differences with other populations.
- •Turkish Cypriot autosomal STR dataset is now available for the forensic community.
Abstract
Fifteen autosomal short tandem repeat (STR) markers [D8S1179, D21S11, D7S820, CSF1PO,
D3S1358, THO1, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA]
were analyzed in 501 unrelated, randomly selected Turkish Cypriot individuals from
the island of Cyprus. While no locus duplications or null alleles were detected in
these samples, eight allelic variants were observed in total, 75% of which were intermediate
allelic variants that were absent in the system allelic ladder. Allelic frequencies
and statistical parameters of forensic interest were calculated at each locus. For
the 15 STR loci tested, combined matching probability (pM) was 2.15717 × 10−18 and combined power of exclusion (PE) was 0.9999995213. No deviations from the Hardy-Weinberg
equilibrium were observed, except for the vWA locus, which became insignificant after
the Bonferroni correction for multiple testing. Locus-by-locus comparisons of the
Turkish Cypriot allelic frequencies with those published for the neighboring and/or
historically related populations with similar loci coverage (Turkish, Greek, Greek
Cypriot, Italian and Lebanese) revealed some statistically significant differences
at one to five loci. In general, an increase in the number of such significant differences
between the Turkish Cypriot data and those for other populations correlated closely
with an increase in the geographic distance and/or a decrease in the amount of historical
contact. The Turkish Cypriot autosomal STR population study will find immediate use
in the Committee on Missing Persons in Cyprus Project on the “Exhumation, Identification
and Return of Remains of Missing Persons” and it will also be available for criminal,
parentage and other missing person investigations.
Keywords
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Article info
Publication history
Published online: September 14, 2014
Received:
July 7,
2014
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
