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Research Article| Volume 16, P13-16, May 2015

Do low template DNA profiles have useful quantitative data?

  • Duncan Taylor
    Correspondence
    Corresponding author at: Forensic Science South Australia, 21 Divett Place, Adelaide, SA 5000, Australia. Tel.: +61 8 8226 7700; fax: +61 8 8226 7777.
    Affiliations
    Forensic Science South Australia, 21 Divett Place, Adelaide, SA 5000, Australia

    School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia
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  • John Buckleton
    Affiliations
    ESR, Private Bag 92021, Auckland 1142, New Zealand
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Published:November 14, 2014DOI:https://doi.org/10.1016/j.fsigen.2014.11.001

      Abstract

      A set of low template mixed DNA profiles with known ground truths was examined using software that utilised peak heights (STRmix™ V2.3) and an adapted version that did not use peak heights and mimicked models based on a drop-out probability [
      • Gill P.
      • Whitaker J.P.
      • Flaxman C.
      • Brown N.
      • Buckleton J.S.
      An investigation of the rigor of interpretation rules for STR's derived from less that 100 pg of DNA.
      ,
      • Balding D.J.
      • Buckleton J.
      Interpreting low template DNA profiles.
      ] (known as semi-continuous or ‘drop’ models) (STRmix™ lite). The use of peak heights increased the LR when Hp was true in the vast majority of cases. The effect was most notable at moderate template levels but was also present at quite low template levels. There is no level at which we can say that height information is totally uninformative. Even at the lowest levels the bulk of the data show some improvement from the inclusion of peak height information.

      Keywords

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