Highlights
- •This study provided the first 23 Y-STR haplotype data set for Tibetan population.
- •PPY23 marker set provided potent discriminatory power for forensic purpose in Tibetan population.
- •Part of null types at DYS448 observed with PPY23 kit should be with caution.
- •Their true type but not null could be obtained by other kit or methods.
Abstract
Tibetan is one of 56 ethnic groups in China, where a level of genetic sub-structure
might be expected. Although a global analysis of Y-chromosomal haplotype diversity
for 23 STR loci and Y-STR databases with PPY23 kit were created with collaborative
effort, there was a lack of data for Tibetan population. In this study we evaluated
248 unrelated male individuals of Chinese Tibetan living in the Tibet Autonomous Region
to explore the underlying genetic structure of Tibetan populations. These samples
were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390,
DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458,
DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) by using PPY23
kit. A total of 224 different haplotypes were found. Haplotype diversity was 0.9990.
Both Rst pairwise analyses and multidimensional scaling plot showed the genetic structure
of Tibetan population was significantly different from some of Chinese ethnic groups
and neighboring populations. There were few interesting null features at DYS448 observed
by PPY23 that deserved some comment. It revealed that PPY23 marker set provided substantially
stronger discriminatory power in Tibetan population.
Keywords
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Article info
Publication history
Published online: November 29, 2014
Accepted:
November 22,
2014
Received in revised form:
November 21,
2014
Received:
October 3,
2014
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
