Highlights
- •A non-exclusion paternity case revealed a four or six step mutation at D5S818 locus.
- •The alleles in the mother, the child and the father were 13, 11/13 and 7/13.
- •The combined paternity index of 39 autosomal STRs is up to 2.461 × 109.
- •Genotyping of 16 Y-STR loci in the child matched completely with the father.
Abstract
A non-exclusion paternity with multistep mutation in the locus D5S818 was reported.
Examination of 39 autosomal short tandem repeats (STR) loci revealed a mismatch of
the maternally or paternally transmitted allele in the locus D5S818 in the questioned
child. The composition of the alleles of this locus in the mother, the questioned
child and the alleged father are 11/13, 7/13 and 13, respectively. The sequence analysis
of the regions flanking the locus D5S818 of the mother, the questioned child and the
alleged father excluded the possibility of null allele as a cause of the allelic mismatch
in the child. The combined paternity index of 39 autosomal STRs is up to 2.461 × 109. Genotyping of sixteen Y-STR loci in the questioned child matched completely with
the alleged father. The results prove that the alleged father is the biological father
of the questioned child with four-step or six-step microsatellite mutation in the
locus D5S818.
Keywords
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References
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Article info
Publication history
Published online: February 02, 2015
Accepted:
January 29,
2015
Received in revised form:
November 21,
2014
Received:
September 17,
2014
Identification
Copyright
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
