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Genetic population study of Y-chromosome markers in Benin and Ivory Coast ethnic groups

  • Cesar Fortes-Lima
    Affiliations
    Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288, Centre National de la Recherche Scientifique (CNRS), Université Toulouse 3—Paul-Sabatier, Toulouse, France
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  • Nicolas Brucato
    Affiliations
    Leiden University Center for Linguistics, Leiden, the Netherlands
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  • Myriam Croze
    Affiliations
    Section of Evolutionary Biology, Department of Biology II, University of Munich, 82152 Planegg-Martinsried, Germany
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  • Gil Bellis
    Affiliations
    Institut National d’Etudes Démographiques, Paris, France
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  • Stephanie Schiavinato
    Affiliations
    Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288, Centre National de la Recherche Scientifique (CNRS), Université Toulouse 3—Paul-Sabatier, Toulouse, France
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  • Achille Massougbodji
    Affiliations
    Centre d’Etude et de Recherche sur le Paludisme Associé à la Grossesse et à l’Enfance, Faculté des Sciences de la Santé, Université d’Abomey-Calavi, Cotonou, Bénin
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  • Florence Migot-Nabias
    Affiliations
    Centre d’Etude et de Recherche sur le Paludisme Associé à la Grossesse et à l’Enfance, Faculté des Sciences de la Santé, Université d’Abomey-Calavi, Cotonou, Bénin

    Institut de Recherche pour le Développement, UMR 216 Mère et enfant face aux infections tropicales, 4 avenue de l’Observatoire, 75006 Paris, France

    COMUE Sorbonne Paris Cité, Université Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France
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  • Jean-Michel Dugoujon
    Correspondence
    Corresponding author.
    Affiliations
    Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288, Centre National de la Recherche Scientifique (CNRS), Université Toulouse 3—Paul-Sabatier, Toulouse, France
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      Highlights

      • 286 West Africans from five ethnic groups were typed for 17 Y-STRs and 96 Y-SNPs.
      • Statistical analyses show close genetic distances between groups from Ivory Coast and Benin.
      • Significant genetic differentiation was observed between Yoruba groups from Benin and Nigeria.

      Abstract

      Ninety-six single nucleotide polymorphisms (SNPs) and seventeen short tandem repeat (STRs) were investigated on the Y-chromosome of 288 unrelated healthy individuals from populations in Benin (Bariba, Yoruba, and Fon) and the Ivory Coast (Ahizi and Yacouba). We performed a multidimensional scaling analysis based on FST and RST genetic distances using a large extensive database of sub-Saharan African populations. There is more genetic homogeneity in Ivory Coast populations compared with populations from Benin. Notably, the Beninese Yoruba are significantly differentiated from neighbouring groups, but also from the Yoruba from Nigeria (FST > 0.05; P< 0.01). The Y-chromosome dataset presented here provides new valuable data to understand the complex genetic diversity and human male demographic events in West Africa.

      Keywords

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