Highlights
- •Investigates the potential for an adventitious match as a result of a PBSM when a crime profile and person profile from two individuals are the same
- •Demonstrated that the effect of PBSMs is to slightly decrease the adventitious match probability from what it would had the same DNA system been used.
- •This was done by both theory and using simulations.
- •Concludes the probability of an adventitious match between profiles from two individuals being caused by a PBSM in one individual is very small.
Abstract
This paper considers the situation where two DNA systems with differing primers have
been used to produce DNA profiles for loading and searching of a DNA Database. With
any profiling system there exists the possibility of a “primer binding site mutation”
(PBSM). When such a mutation occurs at one of the loci in a profile, it has the effect
that the associated allele is not visible in the profile. In the case where a person
has two different alleles at a given locus (heterozygous) the effect of a PBSM would
be that the profile would appear to be that of an individual with only one allele
at that locus (homozygous).
The paper investigates the potential for an adventitious match as a result of a PBSM
when, for example, a crime profile and person profile that have originated from two
different individuals are found to be the same as a result of a PBSM in one of the
profiles. It is demonstrated, both by theory and using simulations, that the effect
of PBSMs is to slightly decrease the adventitious match probability from what it would
had the same DNA system been used.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Forensic Science International: GeneticsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Forensic DNA Typing.2nd edition. Academic Press, 2005: 133-138
- Matching and partially matching profiles.J. Forensic Sci. 2004; 49: 1-6
- European Network of Forensic Science Institutes (ENFSI): evaluation of new commercial STR multiplexes that include the European Standard Set (ESS) of markers.Forensic Sci. Int. Genet. 2012; 6: 819-826
National Institute for Science and Technology discordance study 29 (2015) (communication from Mike Coble).
Article info
Publication history
Published online: June 27, 2016
Accepted:
June 17,
2016
Received in revised form:
May 18,
2016
Received:
December 16,
2015
Identification
Copyright
© 2016 Elsevier Ireland Ltd. All rights reserved.
