Highlights
- •Comprehensive study of 17 X-STRs in seven Spanish populations.
- •Spanish allele and haplotype frequencies database for forensic purposes.
- •Highly discriminative tool for forensic identification and kinship testing.
Abstract
The currently developed 17 X-STR panel (DXS8378, DXS9898, DXS7133, GATA31E08, GATA172D05,
DXS6801, DXS7423, DXS6809, DXS6799, DXS7132, DXS9902, DXS6800, DXS6789, DXS10075,
DXS10079, DXS6807, and DXS6803) offers a highly discriminative tool for forensic identification
and kinship testing. With the aim of providing a global Spanish population X-STR database,
we present haplotype and allele frequencies and parameters of forensic interest for
the 17 X-STR panel obtained from 593 unrelated individuals from Alicante, Aragon,
the Basque Country, Andalusia, Galicia, Madrid, and Barcelona that represent the most
populated regions of the Spanish Peninsular territory. The seven populations were
compared to test possible population genetic substructures. The lack of significant
differences among the studied Spanish populations supports the use of the allele and
haplotype frequency database presented herein as a global Spanish population sample
useful for statistical evaluation in forensic casework. After conducting the LD plots
derived from HapMap and pairwise linkage disequilibrium tests, DXS7132, DXS10075,
and DXS10079 markers were included in a cluster and haplotype frequencies were calculated.
The improvement in the forensic parameters for the Spanish population using 17 X-STRs
in comparison to the previous 10 X-STR allele frequencies database is also shown.
Keywords
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Article info
Publication history
Published online: June 22, 2016
Accepted:
June 22,
2016
Received in revised form:
June 20,
2016
Received:
April 22,
2016
Identification
Copyright
© 2016 Elsevier Ireland Ltd. All rights reserved.
