Correspondence| Volume 24, e14-e16, September 2016

Genetic polymorphism of 22 autosomal STR markers in a Han population of Southern China


      Population genetic data and forensic statistics of 22 autosomal short tandem repeat (STR) loci (D1S1656, D2S1338, D3S3045, D4S2366, D5S2500, D6S477, D7S3048, D8S1132, D9S925, D10S1435, D11S2368, D12S391, D13S325, D14S608, D15S659, D16S539, D17S1290, D18S535, D19S253, D20S470, D21S1270 and GATA198B05) were determined for a sample of 515 unrelated individuals from Han population in Southern China. The expected heterozygosity and the discrimination power varied from 0.7358 to 0.8733 and 0.8915 to 0.9702, respectively. The probability of excluding an unrelated man as the true father (assuming no background relatedness in the population) for trios and for duos ranged from 0.5126 to 0.7415 and 0.3331 to 0.5864, respectively. The studied STRs appear to provide a significant improvement in the statistical power of kinship analysis.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Forensic Science International: Genetics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Gill P.
        • Fereday L.
        • Morling N.
        • Schneider P.M.
        New multiplexes for Europe-amendments and clarification of strategic development.
        Forensic Sci. Int. 2006; 163: 155-157
        • Hares D.R.
        Selection and implementation of expanded CODIS core loci in the United States.
        Forensic Sci. Int. Genet. 2015; 17: 33-34
        • Nothnagel M.
        • Schmidtke J.
        • Krawczak M.
        Potentials and limits of pairwise kinship analysis using autosomal short tandem repeat loci.
        Int. J. Legal Med. 2010; 124: 205-215
        • Skare O.
        • Sheehan N.
        • Egeland T.
        Identification of distant family relationships.
        Bioinformatics. 2009; 25: 2376-2382
        • Carboni I.
        • Iozzi S.
        • Nutini A.L.
        • Torricelli F.
        • Ricci U.
        Improving complex kinship analyses with additional STR loci.
        Electrophoresis. 2014; 35: 3145-3151
        • Chakraborty R.
        • Stivers D.N.
        Paternity exclusion by DNA markers: effects of paternal mutations.
        J. Forensic Sci. 1996; 41: 671-677
        • Kline M.C.
        • Hill C.R.
        • Decker A.E.
        • Butler J.M.
        STR sequence analysis for characterizing normal, variant, and null alleles.
        Forensic Sci. Int. Genet. 2011; 5: 329-332
        • Fung W.K.
        • Chung Y.K.
        • Wong D.M.
        Power of exclusion revisited: probability of excluding relatives of the true father from paternity.
        Int. J. Legal Med. 2002; 116: 64-67
        • Pinto N.
        • Gusmao L.
        • Egeland T.
        • Amorim A.
        Paternity exclusion power: comparative behaviour of autosomal and X-chromosomal markers in standard and deficient cases with inbreeding.
        Forensic Sci. Int. Genet. 2013; 7: 290-295
        • Pinto N.
        • Magalhaes M.
        • Conde-Sousa E.
        • Gomes C.
        • Pereira R.
        • Alves C.
        • Gusmao L.
        • Amorim A.
        Assessing paternities with inconclusive STR results: the suitability of bi-allelic markers.
        Forensic Sci. Int. Genet. 2013; 7: 16-21
        • Walsh P.S.
        • Metzger D.A.
        • Higuchi R.
        Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material.
        Biotechniques. 1991; 10: 506-513
        • Excoffier L.
        • Lischer H.E.
        Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows.
        Mol. Ecol. Resour. 2010; 10: 564-567
        • Goodwin W.
        • Linacre A.
        • Hadi S.
        Forensic parameters.
        An Introduction to Forensic Genetics. Wiley-Blackwell, Chichester, West Sussex, UK2011: 181-182
        • Blouin M.S.
        DNA-based methods for pedigree reconstruction and kinship analysis in natural populations.
        Trends Ecol. Evol. 2003; 18: 503-511
        • Pinto N.
        • Silva P.V.
        • Amorim A.
        General derivation of the sets of pedigrees with the same kinship coefficients.
        Hum. Hered. 2010; 70: 194-204
        • Westen A.A.
        • Haned H.
        • Grol L.J.
        • Harteveld J.
        • van der Gaag K.J.
        • de Knijff P.
        • Sijen T.
        Combining results of forensic STR kits: HDplex validation including allelic association and linkage testing with NGM and Identifiler loci.
        Int. J. Legal Med. 2012; 126: 781-789
        • Gill P.
        • Phillips C.
        • McGovern C.
        • Bright J.A.
        • Buckleton J.
        An evaluation of potential allelic association between the STRs vWA and D12S391: implications in criminal casework and applications to short pedigrees.
        Forensic Sci. Int. Genet. 2012; 6: 477-486
        • Lu D.
        • Liu Q.
        • Wu W.
        • Zhao H.
        Mutation analysis of 24 short tandem repeats in Chinese Han population.
        Int. J. Legal Med. 2012; 126: 331-335
        • Zhang S.
        • Zhang Z.
        • Zhao S.
        • Zhao Z.
        • Li C.
        Genetic polymorphisms in 12 autosomal STRs in a Shanghai Han population from China.
        Electrophoresis. 2013; 34: 613-617
        • Lu D.J.
        • Liu Q.L.
        • Zhao H.
        Genetic data of nine non-CODIS STRs in Chinese Han population from Guangdong Province, Southern China.
        Int. J. Legal Med. 2011; 125: 133-137
        • Zhang S.
        • Tian H.
        • Wu J.
        • Zhao S.
        • Li C.
        A new multiplex assay of 17 autosomal STRs and Amelogenin for forensic application.
        PLoS One. 2013; 8: e57471
        • Zhou A.
        • Wu W.
        • Liu Q.
        • Wu Y.
        • Lu D.
        Population genetic data of the NGM SElect STR loci in Chinese Han population from Zhejiang region.
        Chin. Int. J. Legal Med. 2013; 127: 377-378
        • Lei L.
        • Xu J.
        • Du Q.
        • Fu L.
        • Zhang X.
        • Yu F.
        • Ma C.
        • Cong B.
        • Li S.
        Genetic polymorphism of the 26 short tandem repeat loci in the Chinese Hebei Han population using two commercial forensic kits.
        Mol. Biol. Rep. 2015; 42: 217-225
        • Li J.N.
        • Luo H.B.
        • Song F.
        • Hou Y.P.
        Genetic polymorphisms of 22 autosomal STR loci in Chinese Han population.
        Forensic Sci. Int. Genet. Supp. Ser. 2015; 5: e45-e47