Technological progress made it possible to obtain increasing amounts of forensic genetic
information from increasingly challenging samples. The current capillary electrophoresis
(CE) based megaplexes offer 23 autosomal Short Tandem Repeats (STRs) supplemented
with additional Y-STRs [
1
,
2
]. Massively Parallel Sequencing (MPS) based assays enable the simultaneous analysis
of more than 200 loci. Profiles from degraded, low template samples can show a number
of allelic drop-outs (DOs) which tends to increase with an increased number of analyzed
loci. Calculating the evidential value of such profiles is challenging.To read this article in full you will need to make a payment
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References
- Developmental validation of the PowerPlex® Fusion 6C system.Forensic Sci. Int. Genet. 2016; 21: 134-144
- Developmental validation of the GlobalFiler(®) Express PCR Amplification Kit: a 6-dye multiplex assay for the direct amplification of reference samples.Forensic Sci. Int. Genet. 2015; 19: 148-155
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- Does an English appeal court ruling increase the risks of miscarriages of justice when complex DNA profiles are searched against the national DNA database?.Forensic Sci. Int. Genet. 2014; 13: 167-175
- Inclusion probability with dropout: an operational formula.Forensic Sci. Int. Genet. 2015; 16: 71-76
- Allele frequencies for the new European Standard Set (ESS) loci and D1S1677 in the Belgian population.Forensic Sci. Int. Genet. 2012; 6: e75-e77
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Article info
Publication history
Published online: November 08, 2016
Received:
October 4,
2016
Identification
Copyright
© 2016 Elsevier Ireland Ltd. All rights reserved.
