Abstract
X-chromosomal short tandem repeats (X-STRs) are used to complement autosomal and Y-STRs
in complex kinship testing, and can be of potential value when determining trace female
DNA in male background. We analyzed extracted and directly-amplified samples of 501
males from the United Arab Emirates and report the forensic statistical parameters
of 12 X-STRs and haplotypes of the four previously defined linkage groups using the
Investigator Argus X-12 QS kit. Combined PDM, PDF, MEC Desmarais Trio and MEC Desmarais Duo based on allele (and haplotype) frequencies
were 0.9999999997 (0.999999996), >0.9999999999 (>0.999999999), 0.999999999 (0.999999996)
and 0.9999997 (0.99999994) respectively. No shared profile was observed, and significant
linkage disequilibrium was detected only within the four linkage groups. We calculated
pairwise genetic distance (FST) between our Emirati sample and 35 populations and find they generally mirror biogeography
and historical relationships. We identified 20 distinct off-ladder alleles in seven
loci, the majority of which at DXS10148 and DXS10134. Our analysis reveals that the
12 loci are informative and discriminatory in the Emirati population.
Keywords
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References
- Use of X-linked markers for forensic purposes.Int. J. Legal Med. 2003; 117: 67-74
- X-chromosomal markers: past, present and future.Forensic Sci. Int. Genet. 2007; 1: 93-99
- Forensic typing of short tandem repeat markers on the X and Y chromosomes.Forensic Sci. Int. Genet. 2015; 18: 140-151
- Investigator Argus X-12 QS Handbook.Qiagen, Hilden2015
- United Arab Emirates Federal Competitiveness and Statistics Authority.2017
- Population genetic data for 12 X-STR loci in the Northern Han Chinese and StatsX package as tools for population statistics on X-STR.Forensic Sci. Int. Genet. 2017; 26: e1-e8
- Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows.Mol. Ecol. Resour. 2010; 10: 564-567
- Revised guidelines for the publication of genetic population data.Forensic Sci. Int. Genet. 2017; 30: 160-163
- Genetic polymorphisms of twelve X-chromosomal STR loci in chinese han population from guangdong province.Forensic Sci. Int. Genet. 2011; 5: e114-e116
- Forensic application of investigator Argus X- 12 Kit in han population from East China.J. Forensic Med. 2011; 27: 365-368
- Genetic polymorphisms of twelve X chromosomal STR loci in Han population from Henan Province.J. Forensic Med. 2013; 29: 297-299
- Population data of 12 X chromosome STR loci in Yanbian Korean samples from China.Forensic Sci. Int. Genet. 2014; 13: 143-144
- Genetic polymorphisms of 12 X- STR loci in Guangdong Zhuang population.Forensic. Sci. Technol. 2014; 4: 23-26
- Genetic polymorphisms of 12 X- STR loci in Guangdong Yao population, China.J. Forensic Med. 2014; 4: 365-367
- Population genetics investigation of 12 X chromosome short tandem repeats in the She ethic minority in Fujian, China.J. Fam. Plann. 2011; 19: 628-631
- Genetic analysis of twelve X-chromosomal STRs in Japanese and Chinese populations.Mol. Biol. Rep. 2013; 40: 3193-3196
- Genetic polymorphism and haplotype analysis of 4 tightly linked X-STR duos in Koreans.Croat. Med. J. 2009; 50: 305-312
- Population genetic study of four closelylinked X-STR trios in Koreans.Mol. Biol. Rep. 2010; 37: 333-337
- Genetic study of 12 XSTRs in Malay population living in and around Kuala Lumpur using Investigator Argus X-12 kit.Int. J. Legal Med. 2012; 126: 677-683
- X-chromosomal haplotype frequencies of four linkage groups using the Investigator Argus X-12 Kit.Forensic Sci. Int. Genet. 2012; 6: e24-e34
- Results for five sets of forensic genetic markers studied in a Greek population sample.Forensic Sci. Int. Genet. 2015; 16: 132-137
- A genetic study of 12 X-STR loci in the Hungarian population.Forensic Sci. Int. Genet. 2012; 6: e46-e47
- Expanding X-chromosomal forensic haplotype frequencies database: Italian population data of four linkage groups.Forensic Sci. Int. Genet. 2015; 15: 127-130
- Population data of 12 X-STR loci in a north of Portugal sample.Int. J. Legal Med. 2013; 127: 63-64
- Leonese Dialects in the Portuguese-Spanish Border: A Population Genetic Study Through the Analysis of X-Chromosomal Markers.University of Porto, Porto2011
- Population genetic analysis of 12 X-STRs in Swedish population.Forensic Sci. Int. Genet. 2012; 6: e80-e81
- Investigator Argus X-12 study on the population of Czech Republic: comparison of linked and unlinked XSTRs for kinship analysis.Electrophoresis. 2014; 35: 1989-1992
- Variation of X-chromosomal microsatellites in Belarus within the context of their genetic diversity in Europe.Forensic Sci. Int. Genet. 2015; 16: 105-111
- Analysis of 12 X-STRs in Greenlanders, Danes and Somalis using Argus X-12.Int. J. Legal Med. 2012; 126: 121-128
- Analysis of 21 X-chromosomal STRs in an Algerian population sample.Int. J. Legal Med. 2010; 124: 287-294
- X-chromosome STR markers data in a Cabo Verde immigrant population of Lisboa.Mol. Biol. Rep. 2014; 41: 2559-2569
- Genetic polymorphisms of twelve X-STRs of the investigator Argus X-12 kit and additional six X-STR centromere region loci in an Egyptian population sample.Forensic Sci. Int. Genet. 2014; 11: 26-30
- Allele and haplotype diversity of X-chromosomal STRs in ivory coast.Int. J. Legal Med. 2011; 125: 749-752
- X-chromosomal haplotype frequencies of four linkage groups in a population of Argentina.Forensic Sci. Int. Genet. Suppl. Ser. 2015; 5: e524-e526
- Allele frequency distribution of twelve X-chromosomal short tandem repeat markers in four U. S. population groups.Forensic Sci. Int. Genet. Suppl. Ser. 2011; 3: e481-e483
- DNA Commission of the International Society for Forensic Genetics (ISFG): Guidelines on the use of X-STRs in kinship analysis.Forensic Sci. Int. Genet. 2017; 29: 269-275
- FamLinkX–implementation of a general model for likelihood computations for X-chromosomal marker data.Forensic Sci. Int. Genet. 2015; 17: 1-7
Article info
Publication history
Published online: December 29, 2017
Accepted:
December 28,
2017
Received in revised form:
December 19,
2017
Received:
October 1,
2017
Identification
Copyright
© 2017 Elsevier B.V. All rights reserved.
