Highlights
- •MtDNA suggest a pre/post Columbian genetic continuity in the Colombian Andes.
- •Y-chromosome diversity follows a clinal gradient in the studied region.
- •Sex-biased/male-driven admixture process, involving Pijao women with European men.
- •Admixed closer to Indigenous resguardos have a higher Native American ancestry.
Abstract
Andean populations have variable degrees of Native American and European ancestry,
representing an opportunity to study admixture dynamics in the populations from Latin
America (also known as Hispanics). We characterized the genetic structure of two indigenous
(Nasa and Pijao) and three admixed (Ibagué, Ortega and Planadas) groups from Tolima,
in the Colombian Andes. DNA samples from 348 individuals were genotyped for six mitochondrial
DNA (mtDNA), seven non-recombining Y-chromosome (NRY) region and 100 autosomal ancestry
informative markers. Nasa and Pijao had a predominant Native American ancestry at
the autosomal (92%), maternal (97%) and paternal (70%) level. The admixed groups had
a predominant Native American mtDNA ancestry (90%), a substantial frequency of European
NRY haplotypes (72%) and similar autosomal contributions from Europeans (51%) and
Amerindians (45%). Pijao and nearby Ortega were indistinguishable at the mtDNA and
autosomal level, suggesting a genetic continuity between them. Comparisons with multiple
Native American populations throughout the Americas revealed that Pijao, had close
similarities with Carib-speakers from distant parts of the continent, suggesting an
ancient correlation between language and genes. In summary, our study aimed to understand
Hispanic patterns of migration, settlement and admixture, supporting an extensive
contribution of local Amerindian women to the gene pool of admixed groups and consistent
with previous reports of European-male driven admixture in Colombia.
Keywords
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Article info
Publication history
Published online: June 06, 2018
Accepted:
June 5,
2018
Received in revised form:
June 5,
2018
Received:
February 20,
2018
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
