Highlights
- •A total of 650 Hui males from nine geographical regions in China were genotyped with 157 Y-SNP and 27 Y-STR markers.
- •High haplogroup diversity and haplotype diversity were found in Hui populations.
- •The high-resolution panel with Y-SNPs and Y-STRs indicated that Hui populations can be divided into three groups.
- •Hui populations had close relationships with East Asian populations, especially the Chinese Han population.
Abstract
The Hui group is the second largest ethnic minority and one of the most widespread
ethnic groups in China. However, the genetic architecture of the Hui population remains
largely unexplored, particularly with respect to the male-specific region of the Y
chromosome. Here, we studied nine Hui populations (Xinjiang, Qinghai, Gansu, Ningxia,
Shaanxi, Henan, Shandong, Sichuan, Yunnan) using 157 Y-chromosome single nucleotide
polymorphisms (Y-SNPs) and 27 short tandem repeats (Y-STRs) to unravel their genetic
substructure and forensic characteristics. A total of 650 unrelated male samples from
the Hui populations were genotyped by SNaPshot®, a single base extension (SBE) assay. Finally, 95 terminal haplogroups and high haplotype
diversity (0.9999) were observed in Hui populations. Frequency heat map matrices,
genetic distance (FST) and network analysis within Hui populations indicated that these nine Hui populations
can be divided into three groups: Hui populations from the northwest (NWH), Hui populations
from Sichuan and Shandong (SSH), and Hui populations from Yunnan (YNH). Our results
suggested that we should use different databases for different Hui samples in forensic
cases. Comparison with other populations that used different population genetic analysis
revealed that the Hui populations had close relationships with East Asian populations,
especially Chinese Han population. Overall, the high-resolution panel with Y-SNPs
and Y-STRs gives new and complete insight into Hui populations, which can be used
to interpret the genetic substructure of Hui populations and affect the utility of
forensic databases.
Keywords
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Article info
Publication history
Published online: March 25, 2019
Accepted:
March 23,
2019
Received in revised form:
March 20,
2019
Received:
December 8,
2018
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
