Due to the greatly increased discrimination power compared to the commonly analyzed
control region, sequencing of entire mitochondrial genomes has become a commonly used
approach in the fields of population and forensic genetics [
1
,
- Just R.S.
- Scheible M.K.
- Fast S.A.
- Sturk-Andreaggi K.
- Röck A.W.
- Bush J.M.
- Higginbotham J.L.
- Peck M.A.
- Ring J.D.
- Huber G.E.
- Xavier C.
- Strobl C.
- Lyons E.A.
- Diegoli T.M.
- Bodner M.
- Fendt L.
- Kralj P.
- Nagl S.
- Niederwieser D.
- Zimmermann B.
- Parson W.
- Irwin J.A.
Full mtgenome reference data: Development and characterization of 588 forensic-quality
haplotypes representing three U.S. populations.
2
]. Mitochondrial DNA (mtDNA) is maternally inherited without recombination and is present
in cells in multiple copies, which favors studies of limited amounts or damaged biological
material. Another property – high mutation rate – has become an informative source
allowing to distinguish between separate populations and individuals and to study
female-specific aspects of the demographic history [
- Brandhagen M.D.
- Just R.S.
- Irwin J.A.
Validation of NGS for mitochondrial DNA casework at the FBI laboratory.
Forensic Sci. Int.: Genet. 2020; 44102151https://doi.org/10.1016/j.fsigen.2019.102151
[3]
].Keywords
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Article info
Publication history
Published online: April 20, 2022
Accepted:
April 18,
2022
Received in revised form:
April 17,
2022
Received:
February 17,
2022
Identification
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© 2022 Elsevier B.V. All rights reserved.
